Analysis Note

Colour (visual): white to yellow to beigeAppearance of substance (visual): beadsLoading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.80 mmol/gSwelling Volume (in DMF): lot specific result

General description

Ramage Amide AM resin comprises Ramage′s

dibenzocycloheptadiene linker [1] attached to

aminomethylated polystyrene. Following Fmoc removal, the

resin can be acylated under standard conditions and used in

Fmoc SPPS. The linker is considerably more acid sensitive

than the Rink amide or PAL linkers. This enables peptide

amides to be released from the resin with 3% TFA in DCM

and thus makes it a useful tool for the synthesis of acid

sensitive peptides or protected peptide fragments.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany